Horticultural therapy is gaining acceptance worldwide as an effective treatment to help improve health and well-being. Therefore, universities provide an ideal backdrop for developing and implementing horticultural therapy programming. As a member of the Land Grant Universities, the University of Tennessee has a good foundation for horticultural therapy. Taking the University of Tennessee Gardens (UTG) horticultural therapy program as an example, we elaborated on the development and specific aspects of the UTG horticultural therapy program from three parts: education and training, scientific research, and technology promotion, as well as the importance of horticultural therapy in collaboration with university campuses and community parks. In addition, plans for the UTG horticultural therapy program were discussed to provide a model for other university campuses and community parks to develop horticultural therapy businesses and thereby promote the health and well-being of people.