In recent decades, a great deal has been learned about the power of nature in restoring health and wellness. As a result, many gardens and gardening programs have been developed to serve needy populations. Increasing evidence shows that nature can help heal and strengthen people physically, emotionally, cognitively, and spiritually. The number of sub-healthy people is increasing in today’s fast-paced life and work. This ever-growing population can also use gardens and nature to improve their health and wellness. This chapter explores challenges and stressors at four critical stages along the life course: childhood, emerging adulthood, middle age, and late adulthood. The health and wellness challenges are different at each stage as life course trajectories shift. The positive benefits of bringing nature into one’s life do not change, however, and can increase health and wellness and connection to others and the community at each stage.