Biophilia is the instinctive need for children’s development. However, our children are currently facing the crisis of “lack of nature experience” in the city. It is the responsibility and obligation of the city managers and urban planners to promote children’s biophilia experiences, shaping their physical, emotional, and cognitive growth and bringing them back to a natural and free-playing childhood. This paper analyzes the interaction pattern between children and nature driven by the demand of biophilia needs from the external nature-experiencing behavior and internal place attachment. By summarizing domestic and international literature and practices from theoretical construction to practical application, this paper summarizes the “nature prescription” for reconnecting children with nature with the goal of developing biophilia. Based on the supply level of spatial practices, the guarantee level of policies and regulations, and the support level of social services, we should further improve the supply and services of urban green space, develop a policy management mechanism for children’s connection with nature, encourage bottom-up innovation and digital technology-driven scenarios, and carry out projects from “nearby nature” to “faraway nature”. Explore the biophilia experience models for communities, scenic spots, parks, school districts, rural areas, and other children’s high-frequency contact environments in order to reshape the connection between children and nature.