The harmonious coexistence between man and nature is the philosophical proposition, is also a matter of science. From biological symbiosis, society symbiotic to the harmonious coexistence between man and nature, the connotation of harmonious coexistence is different in the different periods of the civilization. Harmonious coexistence between man and nature in national park has three meanings: life symbiosis, cultural symbiosis, and regional symbiosis. That is, people and wildlife coexist in harmony; the site location and landscape style of the residential buildings and facilities of recreation, the management and protection should respect the historical heritage, inherit landscape culture, protect local cultural ecology. The ecological service flow and ecological product value flow of national park must benefit local residents and drive regional development. Regional communities should actively support the protection of national park ecosystem. According to AGIL model theory, it is necessary for the harmonious coexistence of national parks to develop a benign and sustainable mechanism to promote conservation, including management ability education, social harmonious, protection culture. Therefore, the article proposes four mechanisms for the harmonious coexistence of man and nature in national parks: a continuous and diversified capital investment mechanism, an integrated mechanism for national parks and regional development, a multiple development mechanism for national park communities, and a dynamic and real-time monitoring and feedback mechanism; and four approaches : efficient management system, shrewd protection policy, scientific management planning, strict protection supervision and punishment.