Urban air pollution is becoming more and more serious, and urban ventilation corridors help the diffusion of air pollutants and improve the atmospheric environment. Computational fluid dynamics can analyze, calculate and predict flow fields such as different velocity fields and mass concentration fields, and realize the simulation of wind speed, atmospheric particulate pollutants, building density and other factors appropriately. The study takes Jiaozuo, a traditional industrial city in Henan province, as an example. Firstly, through the spatial and temporal distribution of atmospheric particulate pollutants, the pollution concentration and the main impact space are determined. Secondly, based on the urban wind rose map and green infrastructure, the prevailing wind entering the city tuyere zone and the oxygen supply area were identified. Then, computational fluid dynamics simulation was used to determine the potential ventilation corridors. Finally, identify potential oxygen supply corridors through ventilation balance. The analysis method of ventilation corridor based on computational fluid dynamics can provide a useful reference for the construction of urban ventilation corridors.